Eastern Panama Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

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  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

Top Eastern Panama Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Villas Residences by Playa Caracol Resorts

Villas Residences by Playa Caracol Resorts

3.5 out of 5
Price was CA $1,860, price is now CA $1,351 per person
CA $1,351
per person
Jan 30 - Feb 6
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
8/10 Very good! (9 reviews)
Everything was more then expected, I would definitely stay again, keep up the great service, and hospitality thank everyone on your staff personally from me....

Reviewed on Nov 3, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was CA $4,982, price is now CA $2,264 per person
CA $2,264
per person
Dec 26 - Dec 31
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9.2/10 Wonderful! (1,015 reviews)

Hotel Casa Panamá

Hotel Casa Panamá

4 out of 5
Casco Viejo
Price was CA $1,879, price is now CA $1,370 per person
CA $1,370
per person
Dec 11 - Dec 17
found 23 hours ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
7.6/10 Good! (764 reviews)

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was CA $2,297, price is now CA $1,677 per person
CA $1,677
per person
Dec 26 - Dec 31
found 1 day ago
Roundtrip flight included
Toronto (YTO) to Panama City (PTY)
9/10 Wonderful! (6,099 reviews)
Lovely hotel

Reviewed on Nov 8, 2026

Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
San Francisco
Price was CA $2,393, price is now CA $1,774 per person
CA $1,774
per person
Dec 30 - Jan 5
found 1 day ago
Roundtrip non-stop flight included
Toronto (YTO) to Panama City (PTY)
8.6/10 Excellent! (1,727 reviews)
Well ,it was in great location...but we had a 16 hour layover from Coloumbia and this was beautiful choice but I wish we could have had breakfast xmwith them because we was not staying overnight and thought they would accommodate us because of flight left at 10:29...and I did call them but kno one every pick up the phone.Sothat is issue the price was good😞❤️

Reviewed on Nov 7, 2026

Ready to book your vacation to Eastern Panama?

 

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Eastern Panama Hotel Deals

Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande Isla Grande Colon
The price is CA $636 per night from Nov 10 to Nov 11
CA $636
CA $700 total
Nov 10 - Nov 11
includes taxes & fees
10/10 Exceptional! (16 reviews)
"The best place in the world to have a relax and amazing vacation."

Reviewed on Nov 5, 2026

Ordovician Beach Resort
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island Narganá Guna Yala
The price is CA $266 per night from Nov 10 to Nov 11
CA $266
CA $292 total
Nov 10 - Nov 11
includes taxes & fees
10/10 Exceptional! (1 review)
"Staff was wonderful. Room was basic, as described. Basically camping on the beach with a comfortable bed. Fall asleep to ocean waves just feet from the door."

Reviewed on Mar 15, 2026

Private Ocean-Front Cabin with private bathroom on San Blas Island
san blas luxury tour

san blas luxury tour

2 out of 5
guna yala Nusatupo Guna Yala
The price is CA $153 per night from Nov 13 to Nov 14
CA $153
CA $172 total
Nov 13 - Nov 14
includes taxes & fees
san blas luxury tour
See all 194 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Stay near popular Eastern Panama attractions

Isla Diablo

Commune with nature and explore the great outdoors at Isla Diablo during your travels in San Blas Islands. Take in the festivals while you're in the area.
See properties

Frequently asked questions

How much does an Eastern Panama vacation package cost?
The most affordable Eastern Panama vacation package is CA $1,351, so your dream getaway can become a reality — without breaking the bank. Bundle flights, hotels and car rentals to tailor make a package that matches your traveling style.
How do I get a cheap travel package to Eastern Panama?
Lock in flights that suit your schedule, add a hotel to your booking and watch the savings pile up with an Eastern Panama vacation package. It's as simple as that! From flights and hotels to rental cars and activities, Expedia is where your cheap getaway begins. And with over 550 air carriers and 1,000,000 hotels around the world to choose from, you won't be short of choice.
What are the top hotels in Eastern Panama?
For hotels in San Blas Islands with friendly service and cozy beds, look up Private Over The Water Cabin On San Blas Island and San Blas Private Over - The - Water Cabin. If you plan to explore Narganá as well, you can look forward to a great night's sleep at Paradise Over The Water Cabins In San Blas or San Blas Private Over - The - Water Cabin.
How far in advance should I book my Eastern Panama vacation?
Smart travelers often reserve their seats as early as possible. You can generally look up international fares on Expedia up to 12 months before your intended flight. If you're booking last minute, don't despair. Low prices sometimes occur just weeks prior to departure.
What does an Expedia Eastern Panama travel package include?
Flights, rental cars and hotels, or any combination of the three — it's your choice. Whether you're visiting Eastern Panama with the kids or traveling by yourself, there's a package to fit every style and budget. Once you've made your booking, why not add on a couple of tours or activities?
What should I know before booking an Eastern Panama travel package?
Booking all the parts of your getaway together is an excellent way to save. Combine your car rentals, flights and hotels into a neat little package. But it's not just hotels. Expedia features all types of properties, including vacation rentals like mountain cabins and city apartments. Your choices are almost endless!
Can I choose my airline with an Eastern Panama Expedia vacation package?
Yes — that's the beauty of an Expedia vacation package. You're in charge! We have access to more than 550 airline partners across the globe, so you have loads of choice when planning your Eastern Panama getaway.
If I'm not able to travel, can I cancel my Eastern Panama vacation package?
You can. We realize life doesn't always go to plan, so we're happy to help if you have to make changes to your Eastern Panama vacation package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may charge you a fee if your booking was made more than 24 hours ago. Look up our Customer Service Portal for more information. Also, check your itinerary for the finer details on change fees.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.