Eastern Panama Vacation Packages

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Your Eastern Panama Vacation

Leave all the planning to us with an Eastern Panama vacation package. With everything organized before you jet off, all you need to do is sit back, chill out and experience this destination's many wonders. Where to start your journey? In the most popular cities, of course. Isla Tigre and Palenque are two great places to kick off your itinerary during your trip to Eastern Panama. When it's time to stop daydreaming and start doing, Expedia will help turn your Eastern Panama vacation into reality.

Top Eastern Panama Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
per person
Aug 29 - Sep 4
found 1 day ago
Roundtrip non-stop flight included
Toronto (YYZ) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
Host was excellent. Great communication and very helpful. The rooms were nice and great value.

Reviewed on Apr. 18, 2025

The Sands by Wynwood House

The Sands by Wynwood House

2 out of 5
Calidonia
per person
Sep 13 - Sep 20
found 21 hours ago
Roundtrip flight included
Calgary (YYC) to Panama City (PTY)
No reviews
Hotel Panamonte

Hotel Panamonte

3.5 out of 5
per person
Sep 13 - Sep 20
found 22 hours ago
Roundtrip flight included
Calgary (YYC) to Panama City (PTY)
9.4/10 Exceptional! (108 reviews)
The grounds where beautiful and the staff was so friendly.

Reviewed on Jul. 19, 2025

The Gray by Wynwood House

The Gray by Wynwood House

2 out of 5
Bella Vista
per person
Sep 13 - Sep 20
found 21 hours ago
Roundtrip flight included
Calgary (YYC) to Panama City (PTY)
No reviews
Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
per person
Sep 13 - Sep 20
found 22 hours ago
Roundtrip flight included
Calgary (YYC) to Panama City (PTY)
No reviews

Ready to book your vacation to Eastern Panama?

 

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Eastern Panama Hotel Deals

Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón
The price is CA $190 per night from Jul 27 to Jul 28
CA $190
CA $209 total
Jul 27 - Jul 28
includes taxes & fees
9.6/10 Exceptional! (4 reviews)
"Such a beautiful place! Lovely view and very close to access to the beach. 5 min small boats ride. Relaxing environment mixing mountain feeling and beach view. Very cozy for family of 2 kids. The people in charge there are exceptional!"

Reviewed on Apr. 19, 2025

Ranchos de Chalia
Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande, Isla Grande, Colon
Superou as expectativas
"Excelente para casais"

Reviewed on May 5, 2025

Get rates
Ordovician Beach Resort
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island, Narganá, Guna Yala
The price is CA $256 per night from Aug 24 to Aug 25
CA $256
CA $282 total
Aug 24 - Aug 25
includes taxes & fees
Private Ocean-Front Cabin with private bathroom on San Blas Island
See all 167 properties in Eastern Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Eastern Panama

Cayos Holandeses

Commune with nature and explore the great outdoors at Cayos Holandeses during your travels in San Blas Islands. Stroll along the seaside or experience the area's festivals.

Cayos Holandeses

Frequently asked questions

How much does an Eastern Panama vacation package cost?
The most affordable Eastern Panama vacation package is CA $1,113, so your dream getaway can become a reality — without breaking the bank. Bundle flights, hotels and car rentals to tailor make a package that matches your traveling style.
How do I get a cheap travel package to Eastern Panama?
Lock in flights that suit your schedule, add a hotel to your booking and watch the savings pile up with an Eastern Panama vacation package. It's as simple as that! From flights and hotels to rental cars and activities, Expedia is where your cheap getaway begins. And with over 550 air carriers and 1,000,000 hotels around the world to choose from, you won't be short of choice.
What are the top hotels in Eastern Panama?
For hotels in San Blas Islands with friendly service and cozy beds, look up Private Over The Water Cabin On San Blas Island and San Blas Private Over - The - Water Cabin. If you plan to explore Narganá as well, you can look forward to a great night's sleep at Paradise Over The Water Cabins In San Blas or San Blas Private Over - The - Water Cabin.
How far in advance should I book my Eastern Panama vacation?
Smart travelers often reserve their seats as early as possible. You can generally look up international fares on Expedia up to 12 months before your intended flight. If you're booking last minute, don't despair. Low prices sometimes occur just weeks prior to departure.
What does an Expedia Eastern Panama travel package include?
Flights, rental cars and hotels, or any combination of the three — it's your choice. Whether you're visiting Eastern Panama with the kids or traveling by yourself, there's a package to fit every style and budget. Once you've made your booking, why not add on a couple of tours or activities?
What should I know before booking an Eastern Panama travel package?
Booking all the parts of your getaway together is an excellent way to save. Combine your car rentals, flights and hotels into a neat little package. But it's not just hotels. Expedia features all types of properties, including vacation rentals like mountain cabins and city apartments. Your choices are almost endless!
Can I choose my airline with an Eastern Panama Expedia vacation package?
Yes — that's the beauty of an Expedia vacation package. You're in charge! We have access to more than 550 airline partners across the globe, so you have loads of choice when planning your Eastern Panama getaway.
If I'm not able to travel, can I cancel my Eastern Panama vacation package?
You can. We realize life doesn't always go to plan, so we're happy to help if you have to make changes to your Eastern Panama vacation package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may charge you a fee if your booking was made more than 24 hours ago. Look up our Customer Service Portal for more information. Also, check your itinerary for the finer details on change fees.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.